| Name | Sulfo-SMCC sodium |
| Description | Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively. |
| In vitro | Sulfo-SMCC, a crosslinker featuring a maleimide group and an N-hydroxysuccinimide ester, is designed to attach to sulfhydryl groups and primary amines, respectively. It effectively prevents the longitudinal fusion of stabilized Microtubules (MTs), which retain a consistent mean length regardless of incubation duration. This has been demonstrated in experiments where MTs, upon treatment with 250 μM Sulfo-SMCC, were observed at intervals of 0 hours, 6 hours, and 24 hours, showing no change in length over time[1]. |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 12 mg/mL (27.50 mM), Sonication is recommended.
DMSO : 125 mg/mL (286.45 mM), Sonication is recommended.
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| Keywords | Inhibitor | Sulfo SMCC sodium | SulfoSMCC sodium | ADC Linkers | Antibody-drug conjugates linkers | inhibit | Sulfo-SMCC sodium | Sulfo-SMCC |
| Inhibitors Related | Succinic anhydride | DSS Crosslinker | Val-cit-PAB-OH | Fmoc-8-amino-3,6-dioxaoctanoic acid | Fmoc-Gly-Gly-OH | SMCC | Boc-NH-PEG4-CH2COOH | EMCS | DSG Crosslinker | FMoc-Val-Cit-PAB-PNP |
United States
