| 名称 | Sulfaguanidine |
| 描述 | Sulfaguanidine (Guanicil), a sulfonamide, is served as an anti-infective agent. |
| 体外活性 | Adult rats exhibit a more robust elimination capability for Sulfaguanidine when compared to neonatal rats. Pharmacokinetic studies of gastrointestinal absorption reveal that, following oral administration, the peak plasma concentration in adult rats is significantly lower than that in neonatal rats, although there is no marked difference in the time taken to reach peak blood levels. The absolute bioavailability in adult rats (12.76%) is approximately one-fifth that of neonatal rats (57.86%). In adults, the plasma elimination of Sulfaguanidine, administered intravenously at doses of 2.5 or 25 mg/kg, can be described by a two-compartment open model. Conversely, the plasma concentration profile of Sulfaguanidine, post oral administration of 25 mg/kg, is consistent with a one- or two-compartment open model. Consequently, Sulfaguanidine is less readily absorbed in adult rats, while neonatal rats demonstrate effective absorption. |
| 体内活性 | Sulfaguanidine, one of the earliest sulfa drugs employed in the treatment of intestinal infections, effectively inhibits the synthesis of nutritional factors in intestinal bacteria. It also efficiently impedes the growth of Gram-negative enterobacteria. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 55 mg/mL (256.71 mM)
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| 关键字 | Inhibitor | inhibit | dysentery | enteric | bacillary | antimicrobial,antibiotic | Sulfaguanidine | sulfonamide | Bacterial | Antibiotic | infections |
| 相关产品 | Neomycin sulfate | Stavudine | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Guanidine hydrochloride | Doxycycline | Paeonol | Naringin | Dimethyl sulfoxide | Salicylic acid |
| 相关库 | 经典已知活性库 | 抗生素库 | 药物功能重定位化合物库 | 药物片段库 | NO PAINS 化合物库 | 抗癌上市药物库 | 已知活性化合物库 | 抗癌化合物库 | 人代谢物化合物库 | 抗癌药物库 |
United States
