Basic information Safety Related Supplier

ChemicalBook Product Catalog SSD114 HCl

1/1

SSD114 HCl NEW

$32.00 1mg

$80.00 5mg

$122.00 10mg

Min. Order
Purity99.03%
Cas No2319790-02-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	SSD114 HCl
CAS No	2319790-02-6
EC-No
Min. Order
Purity	99.03%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	SSD114 HCl
Description	SSD114 is a novel GABAB receptor positive allosteric modulator.
In vitro	In conditions containing 10 μM GABA, 25 μM SSD114 hydrochloride significantly increased the level of [35S]GTPγS activation induced by GABA alone to approximately 170% of basal levels.SSD114 hydrochloride (15 or 30 μM) caused a shift in the GABA concentration-response curve to the left and at the highest concentration slightly increased the maximal stimulatory effect of GABA. In the co-presence of 15 and 30 μM SSD114 hydrochloride, the EC50 of GABA was reduced by 2-fold and 2.5-fold, respectively, while the maximal stimulatory effect (Emax) was enhanced only at the 30 μM concentration to 161 ± 5.09% of the basal value [1].
In vivo	SSD114 hydrochloride pretreatment significantly shortened the onset time of the loss-of-orientation reflex (LORR) [F(5,30)=4.55, P<0.005]. Follow-up analyses showed that the onset time of LORR was significantly shorter in the group of mice that received pretreatment at doses equal to or higher than 10 mg/kg SSD114 hydrochloride compared to the control group. In addition, SSD114 hydrochloride pretreatment prolonged the duration of LORR [F(5,30)=4.81, P<0.005]. Follow-up analysis indicated that the LORR duration was significantly prolonged in the group of mice receiving 10 and 100 mg/kg SSD114 hydrochloride pretreatment compared to the control group [1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 45 mg/mL (116.03 mM)
Keywords	SSD-114 hydrochloride \| SSD114 Hydrochloride \| SSD-114 Hydrochloride \| SSD 114 Hydrochloride
Inhibitors Related	Valproic acid sodium salt \| DL-Menthol \| β-Alanine \| Penicillin G sodium salt \| Halothane \| Valproic Acid \| Chlorothymol \| Piperazine citrate \| Riluzole \| Gabapentin \| Nikethamide \| (-)-α-Pinene
Related Compound Libraries	Target-Focused Phenotypic Screening Library \| Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Ion Channel Targeted Library

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book