| 名称 | (S,R,S)-AHPC hydrochloride |
| 描述 | (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
| 体外活性 | Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used |
| 存储条件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10 mM
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| 关键字 | (S,R,S) AHPC hydrochloride | VHL Ligand 1 Hydrochloride | VH032-NH2 | (S,R,S)AHPC hydrochloride | inhibit | (S,R,S)-AHPC | VHL ligand 1 | Ligands for E3 Ligase | Protein degrader 1 Hydrochloride | VHL ligand-1 | ULM1 | E3 ligase-recruiting Moiety | VHL ligand1 | ULM 1 | Inhibitor | AHPC Hydrochloride |
| 相关产品 | Lenalidomide-Br | (S,R,S)-AHPC | Thalidomide | (S,R,S)-AHPC | Pomalidomide | Lenalidomide | Thalidomide-5-OH | 5-Aminothalidomide | Thalidomide 5-fluoride | Thalidomide-4-OH |
United States
