Spermidine
Bulk supplier | spermidine free base; 1,5,10-triazadecane | CAS 124-20-9 | polyamine metabolite | pathgene
Spermidine is a naturally occurring triamine and polyamine metabolite. CAS 124-20-9 identifies the free-base form with formula C7H19N3 and molecular weight 145.25 g/mol. It is used in analytical and formulation development, polyamine research and ingredient screening where the free base, rather than a hydrochloride salt, is the required chemical form.
Free base or salt
The free base is relevant to studies that calculate spermidine on a free-base basis or need a liquid material for dilution and analytical preparation. The reviewed COA describes a colorless liquid and includes anhydrous assay, methanol residue and trace-metal fields, which are useful when building a solution or dosing calculation.
Why it fits: Spermidine is a polycationic amine that interacts with acidic biomolecules; its apparent behavior changes with pH and counterion. That is why a free-base record should not be merged with spermidine trihydrochloride, even though both supply the same parent polyamine.
Product distinction
The free base is 145.25 g/mol, while spermidine trihydrochloride is 254.63 g/mol and is a water-soluble solid. A customer targeting 10 mg of spermidine itself must use the active-basis calculation and not the salt mass without accounting for the three hydrochloride equivalents.
Technical selection points
· The reviewed COA records MS identification consistent with the structure.
· Purity was 99.3% and dry-basis assay was 99.1% in the reviewed batch.
· The COA reports a colorless liquid, water ≤0.5% and methanol not detected.
Selection note: State free base versus trihydrochloride, active-basis calculation, solution concentration and intended use in the RFQ. Reconcile the controlled batch record before using production date or expiry claims in a release decision.
Product identity
Field | Value |
Chemical name | Spermidine |
CAS | 124-20-9 |
Molecular formula | C7H19N3 |
Molecular weight | 145.25 g/mol |
Material type | polyamine metabolite |
Documented batch evidence
The figures below are from pathgene COA PGSPD-260611 and describe one historical lot. They are not a blanket specification for every future shipment.
Test | Release requirement | Batch result |
Purity | ≥99.0% | 99.3% |
Assay on anhydrous basis | 98.0-102.0% | 99.1% |
Largest single impurity | ≤0.3% | 0.23% |
Water content | ≤0.5% | 0.26% |
Methanol residue | ≤3000 ppm | N.D. |
Heavy metals | Pb ≤0.5 ppm; Hg ≤0.3 ppm; Cd ≤0.5 ppm; As ≤0.5 ppm | Reported values comply |
Batch PGSPD-260611; Production and test dates are recorded on the batch COA; verify against the controlled batch record. Pack recorded for this lot: 10 kg/drum. Storage statement: tightly stoppered, dark, 2-8°C.
Application boundary
Research findings and chemical function explain why this material may fit a development program; they do not establish a treatment effect, a recommended human dose or government approval. Finished-product suitability remains dependent on the intended market and formulation.
References
· PubChem Spermidine: https://pubchem.ncbi.nlm.nih.gov/compound/124-20-9
· CAS Common Chemistry record via PubChem: https://commonchemistry.cas.org/detail?cas_rn=124-20-9
· pathgene ingredient catalog: https://pathgenebio.com/en/ingredients/nutrition-functional
For sample and quotation discussions, provide the CAS, intended use, target quantity and required documentation. pathgene website
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