| Name | Sodium 4-phenylbutyrate |
| Description | Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. |
| In vitro | In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels. |
| In vivo | In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 18.6 mg/mL (100 mM)
DMSO : 50 mg/mL (268.56 mM)
|
| Keywords | Histone deacetylases | Autophagy | Benzenebutyric acid | HDAC | 4-PBA | 4-Phenylbutyric acid | Tributyrate | Inhibitor | inhibit | Sodium 4-phenylbutyrate | Apoptosis | Sodium 4 phenylbutyrate | Sodium 4phenylbutyrate |
| Inhibitors Related | Stavudine | 5-Fluorouracil | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Metronidazole | Taurine | Tributyrin | Curcumin | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
