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ChemicalBook Product Catalog SM-164

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SM-164 NEW

$119.00 1mg

$173.00 2mg

$289.00 5mg

Min. Order
Purity99.92%
Cas No957135-43-2
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

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Chemical Properties

Product Name	SM-164
CAS No	957135-43-2
EC-No
Min. Order
Purity	99.92%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	SM-164
Description	SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.
In vitro	SM-164 binds to XIAP being 300 and 7000-times more potent than its monovalent counterparts and the natural Smac AVPI peptide, respectively. The binding affinities of SM-164 to XIAP, cIAP-1, and cIAP-2 proteins are determined using fluorescence-polarization based assays. SM-164 concurrently interacts with both BIR domains in XIAP and functions as an ultra-potent antagonist of XIAP in both cell-free functional and cell-based assays. SM-164 targets cellular XIAP and effectively induces apoptosis at concentrations as low as 1 nM in leukemia cancer cells while having minimal toxicity to normal human primary cells at 10,000 nM. SM-164 has a Ki value of 0.56 nM to XIAP protein containing both BIR2 and BIR3 domains. SM-164 has a Ki value of 0.31 nM to a cIAP-1 protein containing both BIR2 and BIR3 domains. SM-164 binds to cIAP-2 BIR3 protein with Ki values of 1.1 nM [1][2].
In vivo	SM-164 is highly effective in the inhibition of tumor growth and capable of achieving tumor regression in the MDA-MB-231 xenograft model. SM-164 (1 mg/kg) treatment fully inhibits tumor growth during the treatment. SM-164 (5 mg/kg) treatment reduces the tumor volume from 147±54 mm3 at the beginning of the treatment (day 25) to 54±32 mm3 at the end of the treatment (day 36), a reduction of 65%. The strong antitumor activity by SM-164 is long-lasting and not transient. SM-164 (5 mg/kg) is statistically more effective than Taxotere at the end of the treatment (P<0.01) or when the tumor size in the control group reached 750 mm3 (P<0.02) [2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 5.2 mg/mL (4.64 mM), Sonication is recommended.
Keywords	SM164 \| Apoptosis \| SM 164 \| inhibit \| IAP \| Inhibitor \| SM-164
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Acetylcysteine \| Kaempferol \| Myricetin \| Sodium 4-phenylbutyrate \| L-Ascorbic acid \| Dextran sulfate sodium salt (MW 4500-5500) \| Metronidazole \| Sorafenib \| Tributyrin \| Lidocaine hydrochloride
Related Compound Libraries	Apoptosis Compound Library \| Cuproptosis Compound Library \| Bioactive Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| PPI Inhibitor Library \| Bioactive Compounds Library Max

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