Name | SKF 38393 hydrochloride |
Description | SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist. |
In vitro | SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4] |
In vivo | SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol : 6 mg/mL (20.56 mM), Heating is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 45 mg/mL (154.23 mM), Sonication is recommended.
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Keywords | SKF 38393 Hydrochloride | SKF 38393 | SKF-38393 | SKF 38393 hydrochloride | inhibit | Inhibitor | SKF38393 | SKF38393 Hydrochloride | SKF-38393 Hydrochloride | Dopamine Receptor |
Inhibitors Related | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Promazine hydrochloride | Octopamine hydrochloride | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Hypertension Compound Library |