名称 | SK-575 |
描述 | SK-575 is a degradation agent targeting protein-hydrolyzed PARP1 chimera with anticancer and antitumor activity.SK-575 effectively inhibits the growth of cancer cells harboring BRCA1/2 mutations and selectively induces PARP1 degradation in cancer cells. |
体外活性 | In MDA-MB-436, Capan-1, and SW620 cells, SK-575 (10000, 1000, 300, 100, 30, 10, 3, 1, 0.3, 0.1, 0.03, and 0.01 nM; 24 hours) exhibited significant PARP1 degradation activity, with IC50 values of 1.26, 6.72, and 0.509 nM, respectively[1]. |
体内活性 | In male BALB/c nude mice bearing xenograft Capan-1 tumors, SK-575 (25 mg/kg, 50 mg/kg; intraperitoneal injection, once daily for 5 consecutive days) inhibited tumor growth. These doses of SK-575 (25 and 50 mg/kg) were well tolerated, with no observed mouse lethality or significant weight loss during the treatment period[1]. |
存储条件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 80 mg/mL (91.22 mM), Sonication is recommended.
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关键字 | SK 575 | SK-575 | SK575 |
相关产品 | 4'-Methoxychalcone | VPC-70063 | 3-Aminobenzamide | XAV-939 | Niraparib | 3-Methoxybenzamide | NU1025 | Olaparib | Benzamide | OUL35 |
相关库 | 经典已知活性库 | 抗衰老化合物库 | 已知活性化合物库 |