| 名称 | Sincalide ammonium |
| 描述 | Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography. |
| 体外活性 | Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, functions as a novel cardiovascular hormone with a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. It also exhibits a positive role in combating inflammation, apoptosis, and collagen deposition. In the context of H9c2 cardiomyoblasts, CCK‐8 (ammonium) protects cells from Ang II-induced apoptosis, partly through the activation of the CCK1 receptor and the phosphatidylinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway[4]. |
| 体内活性 | In a rat model of myocardial infarction (MI), Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, alleviates fibrosis in the noninfarcted regions. Furthermore, it delays left ventricular remodeling and the progression of heart failure in the MI rat model[3]. |
| 存储条件 | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 30 mg/mL, Sonication is recommended.
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| 关键字 | Sincalide ammonium |
| 相关产品 | PHA-767491 | GV-150013X | Itriglumide | GV150013 | XL413 hydrochloride | Lintitript | Proglumide | N-Cbz-DL-tryptophan | A-65186 | Spiroglumide |
| 相关库 | FDA上市及药典收录分子库 | 经典已知活性库 | 上市药物库 | 膜蛋白靶向化合物库 | 药物功能重定位化合物库 | 已知活性化合物库 | GPCR靶点分子库 |
United States
