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ChemicalBook Product Catalog Chemical Reagents Organic reagents Polycyclic compound Simurosertib

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Simurosertib NEW

$59.00 1mg

$162.00 5mg

$226.00 10mg

Min. Order
Purity99.93%
Cas No1330782-76-7
Supply Ability10g
Update time2025-11-10

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	Simurosertib
CAS No	1330782-76-7
EC-No
Min. Order
Purity	99.93%
Supply Ability	10g
Release date	2025/11/10

Product Introduction

Bioactivity

Name	Simurosertib
Description	Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).
In vitro	Simurosertib effectively inhibits CDC7 kinase activity (IC50 <0.3 nM) with time-dependent ATP-competitive kinetics to its ATP-binding pocket. Treatment with Simurosertib inhibits the cellular MCM2 phosphorylation at Ser40 in a dose-dependent manner, resulting in a delayed S phase progression, DNA-damage checkpoint activation, and caspase-3/7 activation. The selectivity studies using the 308 kinases reveals >120-fold selectivity of Simurosertib for CDC7 kinase inhibition compared to other kinase inhibitions [1].
In vivo	Simurosertib (p.o.) inhibits pMCM2 of the xenografted COLO205 in a dose- and time-dependent manner in the COLO205-xenograft mouse model. Simurosertib shows a significant antitumor activity in multiple xenograft models [1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.86 mM), Sonication is recommended. DMSO : 45 mg/mL (131.8 mM), Sonication is recommended.
Keywords	TAK931 \| TAK 931 \| Simurosertib \| orally \| Inhibitor \| inhibit \| division \| Cyclin dependent kinase \| cycle \| cell \| CDK \| Cdc7 \| ATP-competitive \| anti-cancer
Inhibitors Related	Ribociclib \| Ro-3306 \| Abemaciclib \| Rafoxanide \| AT7519 \| Palbociclib monohydrochloride \| CASIN \| Palbociclib \| GW 441756 \| Sodium Oxamate \| Dinaciclib \| Abemaciclib methanesulfonate
Related Compound Libraries	Anti-Lung Cancer Compound Library \| Anti-Colorectal Cancer Compound Library \| Bioactive Compound Library \| Kinase Inhibitor Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library \| Anti-Cancer Active Compound Library \| Anti-Cancer Drug Library

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