Name | SIB-1553A hydrochloride |
Description | SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment. |
In vitro | In calcium flux assays, compared to nicotine, SIB-1553A hydrochloride (0.1-5 μM) exhibits higher selectivity in both potency and efficacy towards β4 subunits containing recombinant hnAChRs (α2β4, α3beta4, and α4β4) over β2 subunits containing nAChRs (α4β2 and α3beta2)[1]. |
In vivo | In Male Sprague-Dawley rats (200-250 g), SIB-1553A hydrochloride (1, 2, 4, 10, 20, and 40 mg/kg; s.c) induced hippocampal ACh release[2]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : H2O: 20 mg/mL (73.04 mM)
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Keywords | SIB-1553A | SIB1553A | SIB 1553A |
Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Pilocarpine nitrate | CLOZAPINE N-OXIDE | Ribavirin | Adenine | Amitriptyline hydrochloride | Choline chloride | Propoxur |
Related Compound Libraries | Bioactive Compound Library | Neurotransmitter Receptor Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |