1. Materials information
Names
| Name | shanzhiside methyl ester |
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| Synonym | More Synonyms |
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Shanzhiside methylester Biological Activity
| Description | Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1]. |
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| Related Catalog | Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor |
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| Target | IC50: GLP-1 receptor[1] |
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| In Vivo | Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg[1]. |
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| References | [1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 651.4±55.0 °C at 760 mmHg |
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| Melting Point | 90ºC (dec.) |
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| Molecular Formula | C17H26O11 |
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| Molecular Weight | 406.382 |
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| Flash Point | 233.0±25.0 °C |
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| Exact Mass | 406.147522 |
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| PSA | 175.37000 |
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| LogP | -3.25 |
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| Vapour Pressure | 0.0±4.4 mmHg at 25°C |
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| Index of Refraction | 1.621 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods under 50kg
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Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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