| Name | Sertraline hydrochloride |
| Description | Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
| In vitro | Sertraline HCl significantly enhances locomotor activity in mice during the antidepressant Porsolt forced swim test. Intraperitoneal injection of 32 μMol/kg Sertraline HCl inhibits more than 50% of 5-hydroxytryptamine uptake by rat striatal synaptosomes. Sertraline HCl reverses 5-hydroxytryptamine depletion caused by PCA, proving to be six times more effective than chlorpromazine and sixty times more effective than amitriptyline. Acute repetitive administration of Sertraline reduces the serotonin content in whole blood. Chronic administration of Sertraline HCl in rats decreases the binding of [3H] dihydroalprenolol to cortical membranes and the cyclic AMP response to norepinephrine in the limbic forebrain adenylate cyclase. |
| In vivo | Sertraline is more effective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or clomipramine in preferentially inhibiting the uptake of 5-HT (serotonin), with comparatively weaker inhibition of NE (norepinephrine) absorption. However, sertraline exhibits lower selectivity than these agents in blocking the uptake of 5-HT relative to DA (dopamine). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (175.08 mM)
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| Keywords | Inhibitor | inhibit | Antidepressant | Sertraline hydrochloride | SLC6A4 | Sertraline | obsessive | SSRI | Serotonin Transporter | 5-HTT | Sertraline Hydrochloride | SERT | disorder |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
