| Name | Sephin1 |
| Description | Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α |
| In vitro | Sephin1 leads to a strong attenuation of neuronal excitotoxicity independently of the integrated stress response[1]. |
| In vivo | Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (5.09 mM), Sonication is recommended. DMSO : 7 mg/mL (35.6 mM), Sonication is recommended. H2O : insoluble
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| Keywords | Sephin-1 | Sephin1 | protein misfolding diseases | PPP1R15B | PPP1R15A | phosphatase PPP1R15A | Phosphatase | NSC-65390 | NSC65390 | Inhibitor | inhibit | IFB088 | IFB 088 | (E/Z)-Sephin1 | (E/Z)-Icerguastat |
| Inhibitors Related | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | Idoxuridine | Tartaric acid disodium dihydrate | Cyclosporine | Stearic acid | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | CaMKP Inhibitor | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | Trimyristin |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | ReFRAME Related Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | Phosphatase Inhibitor Library |