| Name | Sclareolide |
| Description | Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound. |
| Kinase Assay | Telomerase activity assay: The telomerase activity is measured by the TRAP assay using the TRAPez Telomerase Detection Kit, which includes primers of a 36-bp internal control (IC) for quantifying the amplification of telomerase activity within a linear range close to 2.5 logs. For RNase treatment, 10μL of extract are incubated with 1μg of RNase at 37 °C for 20 minutes. The products of the TRAP assay are resolved by electrophoresis in a nondenaturing12% PAGE in a buffer containing 0.5 × Tris–borate EDTA and detected by autoradiograph. For quantification of TRAP products, the dried gels are exposed to Fuji Imaging Plate at room temperature. Results are corrected for background, and a standard value of 100 is given to the untreated control cell signal. Signal intensities of Costunolide-treated cells are compared to the standard and are expressed as a fraction of the maximum value of 100. [1] |
| In vivo | Sclareolide is utilized in cosmetic fragrances and, despite the lack of clinical evidence, has recently been marketed as a weight loss product. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 47 mg/mL (187.71 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 40 mg/mL (159.76 mM), Sonication is recommended.
|
| Keywords | Staphylococcus aureus | Sclareolide | Pseudomonas aeruginosa | Inhibitor | inhibit | Escherichia coli | Enterococcus faecalis | Bacterial |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | Kanamycin sulfate | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Doxycycline | Dimethyl sulfoxide | Sodium diacetate | BES |
| Related Compound Libraries | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Bitter Compound library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
United States
