| Name | Sclareol |
| Description | Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines. |
| In vitro | Ingestion of Sclareol in rats demonstrates an LD50 greater than 5 g/kg. |
| In vivo | Sclareol inhibits DNA synthesis in human breast cancer cell lines, inducing apoptosis that does not depend on p53 and causing cell cycle arrest at the G(0/1) phase. Intratumoral injection of Sclareol decreases in-vivo growth of breast cancer tumors. It demonstrates growth inhibition and cytotoxicity across various human cancer cell lines. Additionally, Sclareol exhibits anti-inflammatory activity in lipopolysaccharide-stimulated macrophages by reducing the expression of inflammatory cytokines and increasing the activity of antioxidant enzymes. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (16.21 mM), Sonication is recommended.
DMSO : 250 mg/mL (810.37 mM), Sonication is recommended.
Ethanol : 23 mg/mL (74.55 mM), Sonication is recommended.
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| Keywords | Sclareol | Salvia sclarea | P-388 | leukemia | Inhibitor | inhibit | human epidermal?carcinoma? | cell | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Tamoxifen | Urea | Cysteamine hydrochloride | Gum arabic | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Natural Product Library | Tobacco Monomer Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
