| Name | Salvianolic Acid C |
| Description | Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia. |
| In vitro | METHODS: Human periodontal stem cells hPDLSCs were pretreated with Salvianolic acid C (0-5 mM) for 1 h, then cultured with LPS (1 µg/mL) for 24 h. Cytokines were detected using ELISA kits.
RESULTS: Salvianolic acid C treatment significantly inhibited the expression of TNFα, IL-6 and IL-1β in a dose-dependent manner. [1]
METHODS: HEK293T cells stably expressing human-ACE2 were treated with Salvianolic acid C (0-100 µM), and viral entry was studied using the SARS-CoV-2 HSCs pseudovirus (PsV) system.
RESULTS: Salvianolic acid C inhibited SARS-CoV-2 PsV entry on 293T/ACE2 cells with an IC50 of 3.85 µM.[2] |
| In vivo | METHODS: To investigate the effects on liver injury, Salvianolic acid C (5-20 mg/kg) was intraperitoneally injected into C57BL/6J mice with CCl4-induced hepatic fibrosis once a day for six days, followed by APAP (400 mg/kg) to induce liver injury.
RESULTS: Salvianolic acid C protects hepatocytes from APAP-induced injury by attenuating mitochondrial oxidative stress, inflammatory response, and cystatinase-mediated anti-apoptotic effects via inhibition of the Keap1/Nrf2/HO-1 signaling axis. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.5 mg/mL (11.17 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 55 mg/mL (111.69 mM)
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| Keywords | Salvianolic Acid C | inhibit | Inhibitor | CYPs | Cytochrome P450 |
| Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Methoxsalen | Naringin | Naringenin | Tauroursodeoxycholate | Doxepin hydrochloride |
| Related Compound Libraries | 抗癌天然产物库 | 植物来源化合物库 | 天然产物库 | 抑制剂库 | 高通量筛选天然产物库 | 抗衰老化合物库 | 已知活性化合物库 | 古代经典名方目录分子库 | 药食同源库 |
United States
