S-Equol
Bulk supplier | (S)-equol; (-)-S-equol | CAS 531-95-3 | chiral isoflavan metabolite | pathgene
S-Equol is the (3S) enantiomer of equol, a hydroxyisoflavan metabolite associated with soy-isoflavone metabolism. CAS 531-95-3, formula C15H14O3 and molecular weight 242.27 g/mol are supported by the pathgene COA and PubChem. It is supplied for formulation development, analytical work and research on estrogen-receptor ligand systems; the S form should not be presented as equivalent to racemic equol.
Why the S form matters
S-Equol is relevant to products and studies that require a defined single enantiomer, including chiral identity work, receptor-binding research and formulation screening. In a development program, the practical qualification questions are enantiomeric identity, assay, residual solvent and physical stability rather than a generic equol label.
Why it fits: The molecule has a stereocenter and public records identify CAS 531-95-3 with the S configuration. A racemate or an unspecified equol source may have a different enantiomeric composition, so the raw material choice can affect analytical comparability and formulation claims.
Product distinction
S-Equol is distinct from racemic equol and from the R enantiomer. The reviewed COA reports specific optical rotation, but it does not establish a universal enantiomeric-purity specification; buyers should request the chiral method when that attribute is required.
Technical selection points
· The reviewed batch passed infrared identification and solution clarity/color checks.
· Purity and dry-basis assay were both 99.9% in the reviewed batch.
· The COA records melting point 189°C and specific rotation -22° under its stated test condition.
Selection note: For a single-enantiomer product, specify CAS 531-95-3 and request the chiral purity method in addition to the routine assay. Use the historical optical-rotation result as batch evidence, not as a universal release promise.
Product identity
Field | Value |
Chemical name | S-Equol |
CAS | 531-95-3 |
Molecular formula | C15H14O3 |
Molecular weight | 242.27 g/mol |
Material type | chiral isoflavan metabolite |
Documented batch evidence
The figures below are from pathgene COA PGSEQ-260716 and describe one historical lot. They are not a blanket specification for every future shipment.
Test | Release requirement | Batch result |
Purity | ≥98% | 99.9% |
Assay on dry basis | ≥98% | 99.9% |
Loss on drying | ≤1.0% | 0.04% |
Ethanol residue | ≤200 ppm | 76 ppm |
Melting point | 185-195°C | 189°C |
Specific optical rotation | negative rotation requirement under COA method | -22° |
Total plate count | ≤1000 CFU/g | <10 CFU/g |
Batch PGSEQ-260716; 16 July 2026; tested 30 July 2026. Pack recorded for this lot: 1 kg/bag. Storage statement: well-closed, dry, light-protected storage at room temperature.
Application boundary
Research findings and chemical function explain why this material may fit a development program; they do not establish a treatment effect, a recommended human dose or government approval. Finished-product suitability remains dependent on the intended market and formulation.
References
· PubChem Equol: https://pubchem.ncbi.nlm.nih.gov/compound/S-equol
· CAS Common Chemistry record via PubChem: https://commonchemistry.cas.org/detail?cas_rn=531-95-3
· pathgene S-Equol product material: https://pathgenebio.com/en/ingredients/nutrition-functional
For sample and quotation discussions, provide the CAS, intended use, target quantity and required documentation. pathgene website
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