Name | (RS)-(Tetrazol-5-yl)glycine |
Description | (RS)-(Tetrazol-5-yl)glycine (LY 285265) [(D,L-(tetrazol-5-yl)glycine] is an effective and selective N-methyl-D-aspartate receptor agonist with EC50s of 99 nM for GluN1/GluN2D and 1.7 μM for GluN1/GluN2A. |
In vitro | (RS)-(Tetrazol-5-yl)glycine does not significantly inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). It displaces NMDA receptor binding to rat brain membranes using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1]. |
In vivo | (RS)-(Tetrazol-5-yl)glycine is a potent convulsant in neonatal rats (ED50=0.071 mg/kg; i.p.) and induces seizure responses and Fos in NR1+/+ and NR1-/- mice (1.25, 1.5 mg/kg; IP) [1][3]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : < 1.43 mg/mL (10 mM, insoluble or slightly soluble)
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Keywords | LY285265 | Fos | iGluR | GluN2D | (RS)-(Tetrazol-5-yl)glycine | Ionotropic glutamate receptors | inhibit | LY-285265 | Inhibitor | (RS)(Tetrazol5yl)glycine | GluN1 | (RS) (Tetrazol 5 yl)glycine | GluN2A | NMDA | seizure |
Inhibitors Related | Mephenesin | Decanoic Acid | L-Glutamic acid | glycine | Halothane | L-Glutamic acid monosodium salt | Riluzole | D-Cycloserine | Piracetam | Linalool | O-Phospho-L-serine | Procaine hydrochloride |
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