| Name | RP-54745 |
| Description | RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production. |
| Animal Research | 1.5*10^6 peritoneal murine macrophages, after a 2-h period of adherence, were cultured in RPMI 1640 with 5% FCS for 20 h at 37 ℃ in 5% CO2.?In vitro, test compounds were added 15 min before the stimulant, 100ng/ml LPS, and the cells were incubated for 2-24 h. In vivo, thioglycollate-stimulated female OFt mice were orally treated with 5 or 25 mg/kg/day RP 54745 for 4 days.?Harvested macrophages were then stimulated ex vivo for 2 h with LPS at concentrations ranging from 0.1-10 ng/ml.?In some assays, 4 h before macrophage harvesting, mice were treated intraperitoneally with LPS: 0.5 ug per mouse.?At the end of the in vitro incubation period, supernatants were removed from cultures, and cells were lysed by three freeze/thaw cycles.?Both extracellular and cell-associated IL-1 activities were assayed. |
| In vivo | RP-54745 might diminishe?LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1],RP-54745 might influence cells and cytokines implicated in the regulation of the immune system, the disfunctioning of which can lead to inflammatory disorders or autoimmune pathologies[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 62.5 mg/mL (209.86 mM)
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| Keywords | RP 54745 | inhibit | RP-54745 | RP54745 | Inhibitor | Interleukin Related |
| Inhibitors Related | Sodium Thiocyanate | Disulfiram | Deucravacitinib | Apilimod mesylate | Hydrocortisone hemisuccinate | JAK2/STAT3-IN-1 | Y-320 | Balsalazide sodium hydrate | Vidofludimus | Muscone | Apilimod | SC144 |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library | ReFRAME Related Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
United States
