Name | Rottlerin |
Description | Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation. |
In vitro | Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2]. |
In vivo | Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 2 mg/mL (3.87 mM), Sonication is recommended.
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Keywords | inhibit | NSC94525 | Inhibitor | Human immunodeficiency virus | Autophagy | Protein kinase C | Apoptosis | NSC-94525 | HIV | NSC-56346 | NSC56346 | PKC | Rottlerin |
Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | Hydroxychloroquine | Lamivudine | Tributyrin | Oxyresveratrol | Gefitinib | Oleic acid |
Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Viral Compound Library | Anti-infective Natural Product Library | TGF-beta/Smad Compound Library |