| Name | Ro 10-5824 dihydrochloride |
| Description | Ro 10-5824 dihydrochloride is a selective partial agonist of the dopamine D4 receptor, with a Ki of 5.2 nM. |
| In vitro | RO-10-5824 exhibits high affinity binding (Ki=5.2±0.9 nM (n=3)), 250-fold selectivity over human D3R, and >1000-fold selectivity for D4 versus human D2, D1, and D5 receptors. It stimulates 35S-GTPγS binding (EC50: 205±67 nM) (n=7) with a maximal induction of 36±4% above basal level [2]. |
| In vivo | The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 60 mg/mL (169.83 mM)
DMSO : 8.33 mg/mL (23.58 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Ro 105824 dihydrochloride | Ro 10-5824 Dihydrochloride | Dopamine Receptor | Ro 10-5824 | Ro 10 5824 dihydrochloride |
| Inhibitors Related | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Promazine hydrochloride | Octopamine hydrochloride | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
