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ChemicalBook Product Catalog Biochemical Engineering Inhibitors Neuronal Signaling 5-HT Receptor agonists Rizatriptan benzoate

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Rizatriptan benzoate NEW

$39.00 10mg

$72.00 25mg

$128.00 50mg

Min. Order
Purity99.72%
Cas No145202-66-0
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Rizatriptan benzoate
CAS No	145202-66-0
EC-No
Min. Order
Purity	99.72%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Rizatriptan benzoate
Description	Rizatriptan benzoate (MK-462 Benzoate) selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.
In vivo	Rizatriptan blocks neurogenic vasodilation via an action on 5-HT(1D) receptors located on perivascular trigeminal nerves to inhibit CGRP release in anaesthetized guinea-pigs. Rizatriptan evokes a transient reduction in dural blood vessel diameter which recovered to baseline values within 10?min in anaesthetized guinea-pigs. [1] Rizatriptan significantly inhibits dural plasma protein extravasation produced by high intensity electrical stimulation of the trigeminal ganglion. Rizatriptan significantly reduces electrically stimulated dural vasodilation in anaesthetised rats. [2] Rizatriptan Benzoate significantly reduced SP mRNA levels in the midbrains of normal and model group rats, indicating that Rizatriptan Benzoate can downregulate SP gene expression in the rat midbrain. Rizatriptan Benzoate significantly reduces midbrain PENK mRNA expression, decreasing the levels of midbrain met-enkephalin and leu-enkephalin, and thereby weakening the analgesic effects of the endogenous pain modulatory system in rat model of migraine. [3] Rizatriptan Benzoate leads to the number of Fos-like immunoreactive neurons decreased in the spinal trigeminal nucleus caudal partand raphe magnus nucleus, increased the number of Fos-like immunoreactive neurons in the periaqueductal gray and remained unchanged in the ventromedial hypothalamic nucleus and mediodorsal thalamus nucleus in conscious rats. [4] Rizatriptan Benzoate markedly reduces the number of head-flicks in the rats. Rizatriptan Benzoate also significantly reduces the duration of grooming behavior by nearly 2-fold when compared with that without treatment. [5]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 16.67 mg/mL (42.57 mM), Sonication is recommended. H2O : 39.2 mg/mL (100 mM)
Keywords	Rizatriptan benzoate \| MK 462 \| 5-HT Receptor \| Rizatriptan \| Rizatriptan Benzoate \| MK 462 Benzoate \| inhibit \| Inhibitor \| MK462 \| 5-hydroxytryptamine Receptor \| MK-462 \| Serotonin Receptor \| MK462 Benzoate
Inhibitors Related	Alverine citrate \| Olanzapine \| Dapoxetine hydrochloride \| CLOZAPINE N-OXIDE \| Amitriptyline hydrochloride \| Cloperastine hydrochloride \| Trazodone hydrochloride \| Mianserin hydrochloride \| Fluoxetine hydrochloride \| Cinchonidine
Related Compound Libraries	Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Anti-Cancer Approved Drug Library \| FDA-Approved Drug Library \| Bioactive Compounds Library Max \| GPCR Compound Library \| Anti-Cancer Drug Library

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