| CAS: | 123441-03-2 |
| MF: | C14H22N2O2 |
| MW: | 250.34 |
| EINECS: | 602-936-0 |
| Product Categories: |
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| Mol File: | 123441-03-2.mol |
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| Rivastigmine Chemical Properties |
| alpha | D20 -32.1° (c = 5 in ethanol) |
| Boiling point | 316.2±34.0 °C(Predicted) |
| density | 1.038±0.06 g/cm3(Predicted) |
| Fp | 145℃ |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| pka | pKa 8.99 (Uncertain) |
| form | Powder |
| CAS DataBase Reference | 123441-03-2(CAS DataBase Reference) |
| Rivastigmine Usage And Synthesis |
| Uses | Antidepressant |
| Definition | ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor. |
| Brand name | Exelon (Novartis). |
| General Description | Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease. |
| Pharmacokinetics | Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys. |
| Clinical Use |
Mild-moderate dementia in Alzheimer’s disease
Idiopathic Parkinson’s disease |
| Drug interactions | Potentially hazardous interactions with other drugs
Muscle relaxants: enhances effect of suxamethonium; antagonises effect of non-depolarising muscle relaxants. |
| Metabolism | Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds. |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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