Rivaroxaban NEW

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Min. Order1kg
Purity99%
Cas No366789-02-8
Supply Ability20tons
Update time2024-04-07

Shaanxi TNJONE Pharmaceutical Co., Ltd

1YR

China

Chemical Properties

Product Name	Rivaroxaban
CAS No	366789-02-8
EC-No	685-132-2
Min. Order	1kg
Purity	99%
Supply Ability	20tons
Release date	2024/04/07

Description

Rivaroxaban

1. Rivaroxaban is used for adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE).

2. Rivaroxaban is used to treat adult venous thrombosis (DVT) and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT.

3. Rivaroxaban is used for adult patients with nonvalvular atrial fibrillation who have one or more risk factors (such as congestive heart failure, hypertension, age ≥ 75 years, diabetes, stroke or transient ischemic attack history) to reduce the risk of stroke and systemic embolism.

Test Items	Specification	Results
Appearance	White or yellowish powder	White powder
Solubility	Practically insoluble in water,freely soluble in DMSO, Practically insoluble in anhydrous ethanol and in heptanes	Conforms
Identification	IR spectrum should comply with the WS.	Conforms
Identification	HPLC-RT of sample under Enantiometric purity test should comply with that of WS.	Conform
Sulphate ash	Not more than 0.1%	0.0%
Water	Not more than 0.50%	0.21%
Loss on drying	Not more than 0.50%	0.30%
Heavy metal	Not more than 20ppm	Less than 20ppm
Enantiomeric purity	Impurity A:not more than 0.4%	N.D
Related substance	Impurity B: not more than 0.10%Impurity D: not more than 0.10%Impurity E: not more than 0.10%Impurity F: not more than 0.10%Impurity G: not more than 0.10%Impurity H: not more than 0.10%Impurity I: not more than 0.10%Impurity J: not more than 0.10%RVB-4-NJSH: not more than 0.10%Any other unknown impurity: not more than 0.10%Total impurity: not more than 0.3%RVB-HBY:not more than 50ppm	N.DN.D0.02%N.DN.DN.DN.DN.DN.D0.02%0.0%N,D
High molecular protein	NMT 0.5%	N.D
Residual solvent	Ethanol: not more than 5000ppmEthyl acetate: not more than 5000ppmAcetone: not more than 5000ppmN,N-Dimethylformamide: not more than 880ppmMethylene chloride: not more than 600ppmBenzene: not more than 2ppm	N.DN.DN.D526ppmN.DN.D
Assay	98.0-102.0%	99.9%