| Name | Reserpine |
| Description | Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. |
| In vitro | Compared to the control group, alternate-day subcutaneous injections of reserpine solution (1 mg/kg s.c.) for three days significantly increased the duration of vacuous chewing, tongue protrusion, and facial twitching in rats. Reserpine reduced glutamate uptake in the cortical region of rats and caused a significant depletion of vasopressin/oxytocin - neurophysin-like immunoreactivity (LI) and CRH-L1 in the rat's median eminence. Additionally, reserpine notably restored performance in the delayed response task in monkeys. At a dose of 5 mg/kg, reserpine significantly increased pointless jaw movements in monkeys and reduced grooming behavior across all age groups in rats. A subcutaneous injection of 5 mg/kg reserpine in intact rats decreased extracellular dopamine levels to 4% of baseline values. The impact of reserpine on performance in a visual discrimination task, a reference memory task not reliant on the prefrontal cortex, was minimal. |
| In vivo | Reserpine was demonstrated to inhibit efflux pumps in 11, 21, and 48 out of the 102 unrelated clinical isolates tested, resulting in a fourfold decrease in the IC50 values and MICs of sparfloxacin, moxifloxacin, and ciprofloxacin, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (82.14 mM), Sonication is recommended.
|
| Keywords | SVAT | Reserpine | PotassiumChannel | Potassium Channel | MRP1 | MonoamineTransporter | Monoamine Transporter | Inhibitor | inhibit | Bile salt export pump | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Salicylic acid | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Antiparasitic Natural Product Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
