Reichstein's substance S 21-acetate

Name: Reichstein's Substance S 21-acetate
CAS: 640-87-9
Storage Condition: Store at room temperature.
Purity Specification: 99%
Product Category: Bulk Pharmaceutical Chemical
Alias: Hydrocortisone EP Impurity K
Molecular Formula: C23H32O5
Usage: Intermediate for hydrocortisone
Appearance and Physical Properties: Needle-like crystals (from acetone)
Melting Point: 233-235°C
Boiling Point: 537.9±50.0°C (Predicted)
Density: 1.4 g/cm³
Usage: Intermediate for hydrocortisone.
Production Method: It can be prepared by a series of reactions using diosgenin as the starting material, including ring opening, acylation, oxidation, hydrolysis, epoxidation, oxidation, addition of HBr (to introduce bromine at the 16-position), catalytic hydrogenation (to remove bromine), iodination at the 21-position, and substitution of the iodine at the 21-position with an acetoxy group.