Basic information Safety Related Supplier

ChemicalBook Product Catalog RBN012759

1/1

RBN012759 NEW

$107.00 1mg

$263.00 5mg

$455.00 10mg

Min. Order
Purity99.96%
Cas No2360851-29-0
Supply Ability10g
Update time2024-11-14

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	RBN012759
CAS No	2360851-29-0
EC-No
Min. Order
Purity	99.96%
Supply Ability	10g
Release date	2024/11/14

Product Introduction

Bioactivity

名称	RBN012759
描述	RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2]
体外活性	METHODS: B cells were treated with RBN012759 (1 or 0.33 μM ) and added once daily. Cultures were harvested and counted on day 5 and the supernatant was collected for ELISA. RESULTS RBN012759 induced a decrease in IgE. [1] METHODS: RBN0127599 (0.001-10 μM) was tested in IFN-γ stimulated human primary macrophages and RAW264.7 cells to observe the effect of RBN0127599 on the expression of PARP14 protein in vitro. RESULTS The EC50 value (half-maximal effect concentration) observed in RAW264.7 cells was 10 μM, and in human macrophages it was 8 μM, indicating that RBN0127599 showed effective inhibition of the target PARP14 within these concentration ranges. [2]
体内活性	METHODS: RBN012759 (500 mg/kg,i.g) twice daily. Investigators collected plasma samples 2 hours after the last dose (i.e., after the penultimate dose) and on the last day to determine plasma levels of RBN012759 using liquid chromatography-mass spectrometry. RESULTS RBN012759 was effective in reducing allergen-induced IgE (immunoglobulin E) overproduction and mucus overproduction. treatment with RBN012759 resulted in a decrease in overall mucus scores in lung tissue, while the number of inflammatory cells recovered from bronchoalveolar lavage fluid (BALF) and the proportion of eosinophils recovered were significantly reduced in the bronchial-alveolar lavage fluid (BALF) of RBN012759-treated mice. were significantly reduced. [1] METHODS: RBN012759 was tested in a C57BL/6 mouse model by oral administration (BID) at doses of 300 mg/kg and 500 mg/kg for 7 days. RESULTS The 500 mg/kg group showed an increase in PARP14 protein levels, while the 300 mg/kg group did not, indicating that RBN012759 can effectively and specifically target PARP14 in vivo at higher doses. [2]
存储条件	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 12 mg/mL (31.71 mM)
关键字	poly ADP ribose polymerase \| RBN012759 \| pro-tumor \| cancer \| PARP14 \| PARP \| macrophage \| RBN-012759 \| RBN 012759 \| Inhibitor \| inflammatory \| inhibit
相关产品	4'-Methoxychalcone \| Niraparib tosylate monohyrate \| VPC-70063 \| 3-Aminobenzamide \| XAV-939 \| Niraparib \| 3-Methoxybenzamide \| NU1025 \| Olaparib \| Benzamide \| Picolinamide \| OUL35
相关库	抗胰腺癌化合物库 \| 经典已知活性库 \| 抗乳腺癌化合物库 \| 抗卵巢癌化合物库 \| 抑制剂库 \| 抗心血管疾病化合物库 \| 抗衰老化合物库 \| 已知活性化合物库 \| 抗癌化合物库 \| 抗癌活性化合物库

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book