| Name | Raddeanin A |
| Description | Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities. |
| In vitro | METHODS: Raddeanin A (NSC-382873) (1, 2, 5 μM, 20 hours) treated B16-HMGB1-Gluc and MC38-HMGB1-Gluc cells, and measured HMGB1-Gluc luciferase activity and extracellular ATP levels.
RESULTS Raddeanin A induced a significant increase in HMGB1-Gluc activity and ATP release in both B16 and MC38 cells in a dose-dependent manner.[2] |
| In vivo | METHODS: Raddeanin A (NSC-382873) (1, 2, and 4 mg/kg, intraperitoneally or intratumorally) was used to treat mice bearing a subcutaneous xenograft model of MC38 melanoma cells to investigate the effects of Raddeanin A on the immune control of tumor growth in vivo.
RESULTS Raddeanin A caused considerable suppression of tumor size and weight in MC38 tumor-bearing mice; Raddeanin A effectively suppressed tumor growth in mice bearing B16 melanoma; however, intratumoral treatment with Raddeanin A did not significantly alter mouse body weight. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (55.74 mM)
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| Keywords | Cholangiocarcinoma | Apoptosis | NSC 382873 | osteosarcoma | NSC-382873 | Raddeanin A | cancer | prostate | inhibit | Inhibitor |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Tributyrin | Valproic Acid | Curcumin | Salicylic acid | Oleic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Anti-Cancer Active Compound Library |
United States
