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ChemicalBook Product Catalog (Rac)-SAR131675

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(Rac)-SAR131675 NEW

$30.00 1mg

$68.00 5mg

$98.00 10mg

Min. Order
Purity99.1%
Cas No1092539-44-0
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	(Rac)-SAR131675
CAS No	1092539-44-0
EC-No
Min. Order
Purity	99.1%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	(Rac)-SAR131675
Description	(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
In vitro	SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20 nM. SAR131675 dose dependently inhibits rh-VEGFR-3–TK activity with an IC50 of 23 nM. SAR131675 inhibits VEGR-3–TK activity with a Ki of about 12 nM. SAR131675 inhibits VEGFR-1–TK activity with an IC50 of > 3 μM and VEGFR-2–TK activity with an IC50 of 235 nM. SAR131675 inhibits VEGFR-1 autophosphorylation with an IC50 of about 1 μM and VEGFR-2 with an IC50 of about 280 nM. SAR131675 moderately inhibits VEGFR-2 and has very little effect on VEGFR-1, showing a good selectivity for VEGFR-3. SAR131675 inhibits VEGFA-induced VEGFR-2 phosphorylation in a dose-dependent manner, with an IC50 of 239 nM. SAR131675 potently inhibits lymphatic cell survival induced by VEGFC and VEGFD with IC50 of 14 nM and 17 nM, respectively. SAR131675 inhibits VEGFA-induced survival with an IC50 of 664 nM. SAR131675, significantly and dose dependently inhibits VEGFC-induced Erk phosphorylation, with an IC50 of about 30 nM. [1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : Slightly soluble
Keywords	(Rac)-SAR131675 \| Vascular endothelial growth factor receptor \| potent \| (Rac)-SAR-131675 \| Inhibitor \| inhibit \| SAR-131675 \| (Rac) SAR131675 \| VEGFR \| selective \| SAR 131675 \| racemate \| (Rac)SAR131675
Inhibitors Related	Ribociclib \| Nintedanib \| Regorafenib monohydrate \| Sunitinib Malate \| Sorafenib \| Regorafenib \| Sanguinarine chloride \| Nintedanib esylate \| Sorafenib tosylate \| Lenvatinib mesylate \| Pazopanib \| Axitinib
Related Compound Libraries	Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Tyrosine Kinase Inhibitor Library \| Kinase Inhibitor Library \| Inhibitor Library \| Anti-Cardiovascular Disease Compound Library \| Anti-Fibrosis Compound Library \| Bioactive Compounds Library Max \| Covalent Inhibitor Library \| Anti-Cancer Active Compound Library

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