1. Product information
| Product Name: | (R)-(+)-1,2-Dithiolane-3-pentanoic acid |
| Synonyms: | 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]valeric acid;(R)-(+)-1,2-Dithiola;(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid;(R)-Thioctic Acid (R)-1,2-Dithiolane-3-valeric Acid;D-lipoic acid;(R)-(+)-1,2-Dithiolane-3-pentanoic acid 97% |
| CAS: | 1200-22-2 |
| MF: | C8H14O2S2 |
| MW: | 206.33 |
| EINECS: | 638-752-2 |
| Product Categories: | API;Sulfur & Selenium Compounds;Chiral Reagents;Chiral Building Blocks;Heterocyclic Building Blocks;Others;FINE Chemical & INTERMEDIATES;Heterocycles;1200-22-2 |
| Mol File: | 1200-22-2.mol |
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| (R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties |
| Melting point | 48-52 °C(lit.) |
| alpha | D23 +104° (c = 0.88 in benzene) |
| Boiling point | 185-195 °C(Press: 0.5 Torr) |
| density | 1.218±0.06 g/cm3(Predicted) |
| refractive index | 114 ° (C=1, EtOH) |
| Fp | >230 °F |
| storage temp. | -20°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO |
| form | Solid |
| pka | 5.4(at 25℃) |
| color | Light Yellow to Yellow |
| optical activity | [α]20/D +104°, c = 1 in chloroform |
| Merck | 14,9326 |
| LogP | 2.160 (est) |
| CAS DataBase Reference | 1200-22-2(CAS DataBase Reference) |
| Risk Statements | 22-36/38 |
| Safety Statements | 20-36-26-35 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Provider | Language |
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| SigmaAldrich | English |
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| (R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid |
| Uses | A fat-metabolism stimulator |
| Uses | α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection. |
| Definition | ChEBI: (R)-lipoic acid is the (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. It has a role as a prosthetic group, a nutraceutical and a cofactor. It is a lipoic acid, a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It is functionally related to an octanoic acid. It is a conjugate acid of a (R)-lipoate. It is an enantiomer of a (S)-lipoic acid. |
| General Description | α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms. |
| Biochem/physiol Actions | (R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease. |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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