Basic information Safety Related Supplier

ChemicalBook Product Catalog Qstatin

1/1

Qstatin NEW

$38.00 5mg

$64.00 10mg

$118.00 25mg

Min. Order
Purity99.99%
Cas No902688-24-8
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	Qstatin
CAS No	902688-24-8
EC-No
Min. Order
Purity	99.99%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Qstatin
Description	QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species( SmcR with an EC50 of 208.9 nM).
Cell Research	The plasmid pBB1 carrying the LuxRVh homologue-activated lux operon was conjugally transferred into the V. vulnificus wild-type (WT) strain, the ΔsmcR mutant, or the ΔluxO mutant. These V. vulnificus reporter strains were grown overnight, diluted 1:1,000 in fresh LBS, and treated with hit molecules. RLU values were calculated every hour. To determine the EC50, QStatin (10^?12 to 10^?4 M) or 2% DMSO as a control was added to the V. vulnificus WT reporter strain and RLU was measured after 5 h. The percentage of SmcR activity of the sample at a given concentration of QStatin was determined using the following equation: percent SmcR activity = sample RLU/control RLU × 100. The EC50 of QStatin (the concentration reducing the SmcR activity to 50%) was calculated from a plot of the percentages of SmcR activity versus QStatin concentrations using GraphPad Prism 6.0.
In vitro	Because 377B6 [1-(5-bromothiophene-2-sulfonyl)-1H-pyrazole](QStatin) showed the strongest inhibition of SmcR activity without significant growth attenuation of V. vulnificus. SmcR activity was assessed by measuring the RLU level for V. vulnificus WT (pBB1) in the presence of different concentrations of QStatin, which revealed that the half-maximal effective concentration (EC50) of QStatin was 208.9 nM.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 83.33 mg/mL (284.25 mM)
Keywords	inhibit \| Bacterial \| Qstatin \| Inhibitor
Inhibitors Related	Neomycin sulfate \| Dehydroacetic acid sodium \| Ampicillin sodium \| Methyl anthranilate \| Doxycycline (hyclate) \| Kanamycin sulfate \| G-418 disulfate \| Sulfamethoxazole sodium \| Metronidazole \| Doxycycline \| Dimethyl sulfoxide \| Crystal Violet
Related Compound Libraries	Bioactive Compound Library \| Drug-induced Liver Injury (DILI) Compound Library \| Antibiotics Library \| Inhibitor Library \| Anti-Bacterial Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Anti-Infection Compound Library

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book