| Name | Pyoluteorin |
| Description | Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases. Additionally, Pyoluteorin induces apoptosis in human triple-negative breast cancer (MDA-MB-231) cells in vitro. |
| In vitro | Pyoluteorin, an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, was identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1]. It exhibits significant cytotoxicity towards MCF-7 cells (IC50=1.84 μM) and selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50 values of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2]. Treatment with Pyoluteorin (0.1-10 μM; for 24 hours) induces changes in apoptosis-related protein expressions and promotes cell apoptosis in MDA-MB-231 cells via Bcl-2 family proteins and caspase cascade, additionally causing cell cycle arrest in these human triple-negative breast cancer cells[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (202.15 mM), Sonication is recommended.
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| Keywords | Pyoluteorin | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Cysteamine hydrochloride | Kanamycin sulfate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Doxycycline | Tributyrin | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Apoptosis Compound Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Active Compound Library |
United States
