| Name | PY-60 |
| Description | PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation. |
| In vitro | METHODS: PY-60 (20µM, 24 hours) treated 293A cells, and immunoblot analysis of PP2CA-V5 was performed on material obtained by anti-FLAG immunoprecipitation from cells overexpressing ANXA2-FLAG.
RESULTS In 293A cells treated with PY-60, the association between ANXA2 and PPP2CA increased significantly. [1] |
| In vivo | METHODS: PY-60 (5 mg/kg, intravenous injection, 24 hours) was administered to mice, and the changes in plasma levels in mice were evaluated and the intrinsic clearance in mice was measured.
RESULTS The half-life (T1/2) was 0.46 h, and the AUC0-24 was 623 ng*h/mL. At the same time, PY-60 showed a rapid clearance rate (133 mL/min/kg). [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (12.76 mM), Sonication is recommended.
DMSO : 100 mg/mL (319.11 mM), Sonication is recommended.
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| Keywords | YAP | PY-60 | PY60 | PY 60 | AnnexinA | Annexin A2 | Annexin A |
| Inhibitors Related | AICAR | Amcinonide | Timonacic | MY-1076 | YAP-TEAD-IN-3 | Verteporfin | DC-TEADin02 | Dexamethasone acetate | VT103 | VT107 | VT104 | MYF-01-37 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
