Puerarin NEW

Product Description:

  Puerarin, also known as puerarin flavone, is a natural isoflavone carbon glycoside, which is the key component of puerarin to play a medicinal role. Puerarin has the functions of lowering blood sugar, regulating blood lipids, protecting blood vessels, anti-oxidative stress, anti-infection, improving insulin sensitivity index, etc., and has few adverse reactions, known as "phytoestrogen", and is clinically used in the treatment of cardiovascular and cerebrovascular diseases, cancer, Parkinson's disease, Alzheimer's disease, diabetes and diabetic complications.

  Pueraria crude extract and pueraria pueraria can inhibit the proliferation, induce apoptosis and regulate the cell cycle of SMMC-7721 hepatocellular carcinoma cells, and Pueraria crude extract can promote the apoptosis of SMMC-7721 cells. Puerarin can promote the proliferation of human T lymphocytes γδT and improve its killing activity, and the proliferation of γδT cells may be related to the activation of P-ERKl/2 signaling pathway by puerarin and the expression of anti-apoptotic protein Bcl-2. The enhancement of killing activity of γδT cells against SMMC-7721 may be related to the expression of granase B, perforin and CD107a in γδT cells.

Pharmacological action

  Puerarin can remove free radicals, reduce the damage of lipid peroxidation and improve the activity of antioxidant enzymes such as SOD, glutathione peroxidase and catalase. Puerarin can improve immunity, improve microcirculation, dilate blood vessels, increase coronary flow, reduce blood pressure, slow down heart rate and reduce myocardial oxygen consumption, but has no obvious negative inodynamic effect. It also has the effects of antithrombus, raising high density lipoprotein, antivasospasm and reducing platelet aggregation.

Treat diabetes

  Puerarin can treat diabetes by lowering blood glucose concentration. Puerarin can up-regulate insulin receptor substrate IRS-1 and insulin-like growth factor IGF-1 protein, and promote the expression of insulin receptor InsR and peroxisome proliferator-activated receptor PPARα, so as to reduce blood glucose and treat diabetes. In addition, puerarin can also inhibit the activity of α-glucosidase, thereby reducing blood sugar concentration and achieving the purpose of treating diabetes. Studies have found that puerarin drug treatment can improve the body's sensitivity to insulin in type 2 diabetes patients, and puerarin drug can weaken insulin resistance, so as to treat diabetes. Puerarin can also inhibit the production of TNF-α in plasma, improve the body's sensitivity to insulin levels, and reduce blood sugar content. In addition, the application of puerarin in diabetic retinopathy can help to reduce the blood flow resistance of the eye artery, accelerate the blood flow speed, promote muscle artery dilation, and reduce local thrombosis, which has a preventive effect on diabetic retinopathy. Puerarin also has a therapeutic effect on gestational diabetes mellitus.