| Name | Pseudocoptisine chloride |
| Description | Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM). |
| In vitro | In RAW264.7 cells, Pseudocoptisine chloride (0, 60, 90 μM; 1 hour) inhibited LPS-induced NO production in a dose-dependent manner[1]. Pseudocoptisine chloride reduced levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation. Pseudocoptisine chloride (30-90 μM; 1 hour) significantly reduced the LPS-induced TNF-α and IL-6 production and their mRNA expressions[2]. |
| In vivo | Pseudocoptisine chloride (2.0 mg/kg, p.o.) showed anti-amnesic activities on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) and significantly reverses cognitive impairments in mice by passive avoidance test[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1 mg/mL (2.81 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | Isocoptisine | anti-amnestic | Pseudocoptisine chloride | cytokines | anti-inflammatory | Pseudocoptisine | pro-inflammatory | Isocoptisine Chloride | Pseudocoptisine Chloride | RAW 264.7 | Cholinesterase (ChE) | inhibit | Inhibitor |
| Inhibitors Related | 1-Naphthyl acetate | DL-Menthol | Ethyl (triphenylphosphoranylidene) acetate | 4-Methylbenzylidene camphor | Isoeugenol acetate | Diethyltoluamide | sn-Glycero-3-phosphocholine | Nizatidine | Coumaran | Methyl tridecanoate | Trimethylammonium chloride | Trimyristin |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
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