| Name | Prunin |
| Description | Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase. |
| In vitro | The effects of Prunin- and HG-alkyl (C4-C18) esters (0.1-100μM) on human leukemia T (Jurkat) cells viability and plasma membrane fluidity were evaluated. At this concentration, cell hyperpolarization and shrinkage were also observed. Cell plasma membrane fluidity was not affected, regardless the depths of the membrane level evaluated, but mild changes in plasma membrane hydration were found. Esterification did not affect the antioxidant capacity of Prunin and HG (0.1-10μM) against 1mM H2O2. When exposed to 1mM AAPH, P-alkyl esters retained Prunin antioxidant capacity, but HG-derivatives acted as pro-oxidants[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.6 mM), Sonication is recommended.
DMSO : 25 mg/mL (57.55 mM), Sonication is recommended.
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| Keywords | VirusProtease | Virus Protease | synthesis | RNA | Rhinovirus | Prunin | Phosphatase | Inhibitor | inhibit | infection | HRVs | HRV | HMG-CoA reductase | HEVs | HEV | Enterovirus | Anti-infection | Antiinfection | Antifection | anti-diabetic |
| Inhibitors Related | Phenytoin sodium | Levofloxacin hydrochloride | β-Glycerophosphate disodium salt pentahydrate | Hexane-1,6-diol | L-Lysine | Penicillin G potassium | Ofloxacin | Tartaric acid disodium dihydrate | (E)-3-(p-Tolyl)acrylaldehyde | Thymidine | Naringenin | Danthron |
| Related Compound Libraries | Flavonoid Natural Product Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Anti-Viral Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library for HTS | Cosmetic Ingredient Compound Library | Flavor Natural Product library | Bitter Compound library | Anti-infective Natural Product Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
