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Promethazine Hydrochloride HCL Powder Details: (Promethazina/Promethazin em po polvo Poudre)
Product name | Promethazine Hydrochloride |
| CAS No. | 58-33-3 |
| Molecular formula | C17H21ClN2S |
| Molecular weight | 320.88 |
EINECS number | 200-375-2 |
What's Promethazine hydrochloride Powder?
Promethazine hydrochloride is the earliest discovered tricyclic antihistamine with phenothiazine structure. It has antitussive effect and can competitively block the histamine H1 receptor to produce antihistamine effect and resist the capillary effect caused by histamine. Dilate blood vessels and reduce their permeability. Therefore, it is possible to calm coughs caused by irritation of the trachea.
Pharmacological effect:
Promethazine is a phenothiazine antihistamine that can also be used for antiemetic, antimotion sickness and sedative hypnosis.
1. Antihistamine effect: Compete with the histamine released by the tissue for H1 receptors, antagonize the contraction or contraction of histamine on the smooth muscle of the gastrointestinal tract, trachea, bronchi or bronchioles, and relieve the spasm and congestion of the bronchial smooth muscle caused by histamine effect.
2. Antiemetic effect: It may be related to the inhibition of the emetic chemoreceptor area in the medulla oblongata.
3. Anti-motion sickness: It may act on the vestibular and vomiting centers and midbrain medullary receptors through the central anticholinergic function, mainly to block the excitation of the labyrinth impulse of the cholinergic synapse in the vestibular nucleus area. 4. Sedative and hypnotic effect: it may be due to indirectly reducing the excitability of the brainstem ascending reticular activation system.
Indications:
1. Skin and mucous membrane allergies: suitable for long-term, seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis caused by contact with allergens or food, urticaria, angioedema, blood or plasma Allergic reactions to products, skin scratches. If necessary, it can be used in combination with epinephrine as an adjuvant to this drug.
2. Motion sickness: prevent motion sickness, seasickness, and airplane sickness.
3. Sedation and hypnosis: suitable for preoperative, postoperative and obstetrics. In addition, it can also be used to reduce the fear of adults and children, showing a light sleep state.
4. Treatment of nausea and vomiting: It is suitable for nausea and vomiting after some anesthesia and surgery, and is also used to prevent radiation sickness or drug-induced nausea and vomiting.
5. Postoperative pain: It can be used in combination with painkillers as an auxiliary drug.
Company:
Prodessional certification:
China
