Product Name: Progesterone
Synonyms: PROGESTERONE USP;PROGESTERONE, CELL CULTURE TESTED;Progesterone, Topical, Powder, Micronized;grogesterone;HYDROXY PROGESTERRONE CAPTORATE BP98;Progeseterone;(8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;Progesterone,98%
CAS: 57-83-0
MF: C21H30O2
MW: 314.46
EINECS: 200-350-6
Melting point: 128-132 °C (lit.)
Boiling point: 394.13°C
Density: d23 1.166; d20 1.171
Storage temp.: 2ºC
Description:
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.
Application:
The main physiological effects of progesterone:
1. Progesterone can maintain the female animal pregnancy, and cause a series of physiological changes, such as inhibition of female estrus.
2. Progesterone has the power to promote the thickening of the lining of the uterus, promote the bending of the gland and to increase secretion function.
3. Progesterone can inhibit the peristalsis of the uterus, and contribute to the cervix contraction, secretion of mucus, etc.. These physiological changes provide suitable environment for the operation, growth and development of early embryos, as well as the continued growth of the fetus.
4. Small amount of progesterone is also used in combination with the hormone estrogen to promote female estrus. The synergy between progesterone and prolactin can promote the development of mammary glands.
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