The local anesthetic procaine, whose hydrochloride is called novocain. With its hydrochloride, white crystalline or crystalline powder, odorless, slightly bitter taste, followed by paralysis, easily soluble in water. The duration of local anesthesia of procaine is about 1 hour, and the effect can be maintained for 1 to 2 hours if a trace amount of epinephrine is added to the liquid. It has weak penetration of the skin and mucous membranes and is not suitable for use as surface anesthesia. After absorption, this product is mainly hydrolyzed to p-aminobenzoic acid and diethylaminoethanol by plasma pseudocholinesterase. The former can compete against the antibacterial action of sulfonamides and weaken the curative effect of sulfonamides. The latter can enhance the effect of digitalis, and patients who have taken sufficient digitalis should use this drug with caution. When procaine is combined with succincholine, both drugs are hydrolyzed by plasma pseudocholinesterase. In the case of intravenous infusion of large amounts of procaine, it is possible to compete with the hydrolytic enzyme and reduce the hydrolytic inactivation of succincholine, significantly strengthen and prolong its muscle relaxation effect, resulting in respiratory paralysis. If procaine is absorbed in large quantities, it produces excitatory effects on the Chemicalbook system of the central nervous system, and then turns to inhibition, manifested as restlessness, convulsion, coma, respiratory paralysis, and a few patients have allergic reactions. Pharmacological action This product is an ester local anesthetic, which can temporarily block the conduction of nerve fibers and has anesthetic effects. This product has weak penetration to skin and mucous membrane and is not suitable for surface anesthesia. This product on central nervous system macroinhibition, excessive excitation. First causes sedation, dizziness, pain threshold increases, and then causes vertigo, disorientation, ataxia, central inhibition continues to deepen, there is numbness, blurred consciousness, and then into a coma. If the dose continues to increase, the toxic symptoms of central excitation such as muscle tremor, irritability and convulsion may appear. The small dose of this product has the effect of excitatory sympathetic nerve, which makes the heart rate increase and blood pressure rise. The dose increases, and the blood pressure decreases and the heart rate increases due to myocardial inhibition, peripheral vascular dilation and mild ganglion blockade. This product inhibits the release of acetylcholine in the presynaptic membrane, resulting in certain neuromuscular blockade, which can enhance the effect of non-depolarizing muscle relaxants, and directly inhibit smooth muscle and relieve smooth muscle spasm.
Why choose forest chemistry
1. forest chemistry has a professional research and development team and strong technical force to ensure technical support and research capabilities.
2. Made in China and exported to many countries and regions at the most favorable price.
3、Our customers all over the world and have been highly valued and trusted by customers
4、We promise to reply your inquiry within 24 hours, including holidays and holidays.
5, safe and prudent shipping a variety of transportation modes for you to choose.
If you are interested, please feel free to contact us for detailed product specifications, prices, delivery times and payment terms.
Where is the advantage of white forest chemistry industry
1. Chinese origin.
2、 the purity of all products >99%.
3、 high quality products and competitive prices.
4、 Sufficient inventory, fast delivery, and the ability to meet customer needs.
5、 safe and prudent shipping a variety of transportation modes for you to choose.
6、 Clearance rate of multiple ports >99%.
7、 Delivery time within 7 days after payment and 24 hours of quality after-sales service.
With rich experience and professional service,
Forest chemistry has won the trust of customers from diverse countries. Welcome your consultation and sample ordering. We sincerely look forward to cooperating with you!
China
