Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine was first synthesized in 1905, shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was the most commonly used local anesthetic. Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful.
Basic Info
Chemical Name | procaine |
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Synonyms | 4-aminobenzoic acid 2-diethylaminoethyl ester;Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester;PROCAINE; |
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CAS No. | 59-46-1 |
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Molecular Formula | C13H20N2O2 |
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Molecular Weight | 236.31000 |
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PSA | 55.56000 |
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LogP | 2.34860 |
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Properties
Density | 1.077g/cm3 |
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Boiling Point | 373.6ºC at 760 mmHg |
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Melting Point | 61ºC |
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Flash Point | 179.8ºC |
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Refractive Index | 1.542 |
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Safety Info
Hazard Class | 6.1(b) |
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HS Code | 2922499100 |
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Packing Group | III |
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RIDADR | UN 3249 |
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Chemical properties:
white crystal. Melting point 61℃. The dihydrate has a melting point of 51℃, and its hydrochloride ([51-05-8]) is a white crystal or crystalline powder with a melting point of 153-156℃. Soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Odorless, slightly bitter, followed by a tingling sensation. Its aqueous solution is easy to decompose and fail after long storage, exposure or heat.
Pharmacological action:
This product is an ester local anesthetic, which can temporarily block the conduction of nerve fibers and has an anesthetic effect. This product has weak penetration to skin and mucous membrane and is not suitable for surface anesthesia. This product on central nervous system macroinhibition, excessive excitation. First causes sedation, dizziness, pain threshold increases, and then causes vertigo, disorientation, ataxia, central inhibition continues to deepen, there is numbness, blurred consciousness, and then into a coma. If the dose continues to increase, the toxic symptoms of central excitation such as muscle tremor, irritability and convulsion may appear. The small dose of this product has the effect of excitatory sympathetic nerve, which makes the heart rate increase and blood pressure rise. The dose increases, and the blood pressure decreases and the heart rate increases due to myocardial inhibition, peripheral vascular dilation and mild ganglion blockade. This product inhibits the release of acetylcholine in the presynaptic membrane, resulting in certain neuromuscular blockade, which can enhance the effect of non-depolarizing muscle relaxants, and directly inhibit smooth muscle and relieve smooth muscle spasm.
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Company Introduction
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!
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FAQ
What is the way you ship?
Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc
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The company name and other contents related to pharmacy are not written on the package slips.
The way of packing is regularly changed for a secure delivery.
The packages are small in order to avoid unwelcomed questions . If the order is big, then it will be divided into two or more packages
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Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.
Do you ensure your packing , what about customs, what happens if the package is retained?
We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.
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