Name | Pregnenolone Carbonitrile |
Description | Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A. |
In vitro | Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4]. |
In vivo | In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 30 mg/mL (87.85 mM), Sonication and heating to 60℃ are recommended.
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Keywords | CYPs | Cytochrome P450 | P4503A | orally | 5-Pregnen-3b-ol-20-one-16a-carbonitrile | 5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile | Inhibitor | Pregnenolone Carbonitrile | PXR | cytochrome | inhibit | Pregnenolone 16α-carbonitrile | Pregnenolone 16alpha-carbonitrile | Pregnenolone 16a-carbonitrile |
Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Methoxsalen | Naringin | Naringenin | Tauroursodeoxycholate | Doxepin hydrochloride |
Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Anti-Cancer Compound Library | Human Metabolite Library |