| Name | Potassium 1H-indol-3-yl sulfate |
| Description | Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity. |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 3 months | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (397.93 mM), Sonication is recommended. H2O : 50 mg/mL (198.97 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (15.92 mM), Sonication is recommended.
|
| Keywords | Potassium 3-indoxyl Sulfate | Potassium 1H-indol-3-yl Sulfate | Potassium 1Hindol3yl sulfate | Potassium 1H indol 3 yl sulfate | Inhibitor | inhibit | Indoxyl sulfate potassium | EndogenousMetabolite | Endogenous Metabolite | AhR |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Natural Product Library | NO PAINS Compound Library | Anti-Fibrosis Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Immunology/Inflammation Compound Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Human Metabolite Library |