Polyquaternium-1 is a very safe preservative, which shows very low acute toxicity in rats.Polyquaternium-1 is slightly toxic orally (LD50> 4.47 ml/l at 40% active in rats). Polyquaternium-1 is not irritating to skin at 40%. The product is not a skin sensitizer and is non-mutagenic.
Polyquaternium-1 is a detergent-type preservative derived from BAK,also named as Polidronium Chloride,PQ-1.Polyquaternium-1 is formulated in the mid of 1980s by Alcon as a preservative for contact lens storage solutions.Nowadays,it is being increasingly used as a presverative in ophthalmic drops for glaucoma, artificial tear solutions and top cosmetic formuations.
Polyquaternium-1 is a cationic polymer prepared by the controlled polymerization of dimethylamine and bis-dichlorobutene, end capped with tris-b-Hydroxyethylamine.
Key Technical Parameters:
(1) 95~100% Solid:
| Appearance | Amber to dark brown solid |
| Odor | Without Stimulation |
| Water solubility | Full Soluble |
| Free Amine | 5.0% |
| pH | 6.0~9.0 |
| Chloride | <30% |
| Internal standard content | ≥95% |
| Total Number of Aerobic Microbial Count(TAMC) cfu/g | <10³ cfu/g |
| Total Yeasts and Molds Count(TYMC) cfu/g | <10² cfu/g |
(2) 40% liquid :
| Appearance | Light yellow liquid |
| Odor | Without Stimulation |
| Molecular Weight | 30,000~40,000 |
| Solid Content | ≥33% |
| Chloride | ≤10% |
| Free Amin | ≤2.0% |
| pH | 6~9 |
| Water Solubility | 100% Soluble |
| Total Aerobic Microbial Count(TAMC) | <1000cfu/g |
| Total Yeasts and Molds Count(TYMC) | <100 cfg/g |
Applications:
Polyquaternium-1is an antimicrobial preservative, with higher antimicrobial effects and lower ocular irritation.used as bactericide in eye drops,soft lenses product and other ophalmic care products formulation.In skin care formulations,it can help to avoid or reduce the allergy and infection possibility.
*Preservative
*Antimicrobial for use in products targeting mucus membrane or other sensitive tissue
*Antimicrobial for use in dermatological applications and trans-dermal patch pharmaceuticals
*Antimicrobial for use as surface protection for medical devices
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
6.Products can be packaged according to customer requirements.
FAQ
Q1: Can I get samples?
Answer: Of course you can. For most products, we can provide you with free samples, and the shipping costs should be borne by you.We also accept small quantities of 10g, 100g and 1kg orders to evaluate your quality of our products.
Q2: How to place an order for your product?
Answer: First let us know your requirements or applications. Secondly, we quote according to your request or our suggestion.Third, the customer confirms the samples and deposits for the form al order. We can offer discounts for large orders.
Q3: Can you tell us something about shipping?
Shipping can be DHL, UPS, TNT, EMS, Fedex, etc.
If you want to order in large quantities, you can do it by air or sea.
Transportation costs vary according to the mode of transportation and the country you are arriving in. You can tell me your country and mode of transportation, and we will give you the freight price as soon as possible.
Q4: How to make payment?
Payment method: T/T, L/C ,etc.
China
