| Name | Polyinosinic-polycytidylic acid |
| Description | Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals. |
| In vitro | METHODS: Cervical cancer cells HeLa, SiHa, C33A and lung cancer cells A549 were treated with polyinosinic-polycytidylic acid (0.1-1 μg/mL) for 24 h, and cell death was detected using PI Staining.
RESULTS: Polyinosinic-polycytidylic acid effectively induced tumor cell death in a dose-dependent pattern. [1]
METHODS: Rat astrocytes were pretreated with polyinosinic-polycytidylic acid (10-20 μg/mL) for 12 h, and then exposed to oxygen-glucose deprivation (OGD) for 12 h. The morphology of the cells was examined by microscopy.
RESULTS: OGD induced significant cellular damage, and the cells appeared to be healthier in the group pretreated with polyinosinic-polycytidylic acid.Polyinosinic-polycytidylic acid exerted a certain degree of protective effect against OGD-induced damage in cultured astrocytes. [2] |
| In vivo | METHODS: To investigate the neuroprotective effects in an acute ischemia model, Polyinosinic-polycytidylic acid (0.3 mg/kg) was administered as a single intramuscular injection to Kun-Ming strain mice, and a model of arterial occlusion (MCAO) was constructed 2 h later.
RESULTS: Administration of polyinosinic-polycytidylic acid significantly attenuated neurological deficits in the ischemic striatum and cortex, reduced infarct volume, and suppressed the elevation of TNFα and IL-6 levels. [2]
METHODS: To test the antitumor activity in vivo, Polyinosinic-polycytidylic acid (1-100 μg/mouse) was intraperitoneally injected into a mouse model of metastatic tumors C57BL/6J induced by cutaneous melanoma B16-F10.
RESULTS: Lung tumor growth stopped after a single dose of Polyinosinic-polycytidylic acid. Polyinosinic-polycytidylic acid has potential antitumor activity in an established mouse model of lung metastasis. [3] |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : 100 mg/mL, Sonication is recommended.
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| Keywords | Toll-like Receptor (TLR) | TLR3 | Polyinosinic-polycytidylic acid | Polyinosinicpolycytidylic acid | Polyinosinic polycytidylic acid | Inhibitor | inhibit |
| Inhibitors Related | Afimetoran | Resatorvid | Hydroxychloroquine | Chloroquine phosphate | RV01 | Chloranil | Chloroquine | CU-115 | Imiquimod | TLR3-IN-1 | Resiquimod | Stevioside |
| Related Compound Libraries | Nucleotide Compound Library |
United States
