1. Product information
Names
| Name | POLYDIMETHYLSILOXANE |
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| Synonym | More Synonyms |
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Simethicone Biological Activity
| Description | Simethicone is an orally active defoamer. Simethicone reduces the surface tension of air bubbles in the gastrointestinal tract, causing them to be expelled by vomiting, exhalation or absorption into the bloodstream. Simethicone has potential applications in flatulence and colic[1]. |
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| Related Catalog | Research Areas >> Others Signaling Pathways >> Others >> Others |
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| In Vivo | Animal Model: Female adult Wistar rats (200–250 g)[2]. Dosage: 50, 100 and 200 mg/kg. Administration: Oral gavage; single dose. Result: Improved colon permeability and hypersensitivity (200 mg/kg). Animal Model: Adult New Zealand White (NZW) rabbits[3]. Dosage: 20 mg/kg. Administration: Oral gavage; single dose. Result: Improved image quality scores for the jejunum without affecting left kidney, right kidney and gallbladder. |
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| References | [1]. Voepel-Lewis TD, et al. Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants. J Clin Anesth. 1998 Mar;10(2):91-4. [2]. Bueno L, et al. Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association. J Pharm Pharmacol. 2013 Apr;65(4):567-73. [3]. da Silva KG, et al. Influence of simethicone and fasting on the quality of abdominal ultrasonography in New Zealand White rabbits. Acta Vet Scand. 2017 Jul 17;59(1):48. |
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Chemical & Physical Properties
| Density | 1 g/mL at 20ºC |
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| Boiling Point | 96.5ºC at 760 mmHg |
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| Molecular Formula | C6H18O4Si3 |
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| Molecular Weight | 238.46100 |
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| Flash Point | 6.3ºC |
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| Exact Mass | 238.05100 |
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| PSA | 52.60000 |
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| LogP | 1.56770 |
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| Appearance of Characters | emulsion | Colorless |
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| Vapour Pressure | 5 mm Hg ( 20 °C) |
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| Index of Refraction | n20/D 1.406 |
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| Storage condition | room temp |
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| Water Solubility | Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene. |
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2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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