Chinese name: methyl piperonyl epoxypropionate ethyl ester
English name :PMK
CAS number :28578-16-7
CBNumber:CB22731285
Molecular formula :C13H14O5
Molecular weight :250.25
Boiling point :327.8±42.0 °C(Predicted)
Density :1.302± 0.06g /cm3(Predicted)
Solubility :DMF: 15 mg/ml; DMSO: 30 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
InChI: InChI = 1 s/C13H14O5 / c1-3-15-12 (14), 13 (2) 11 18 (13) the 8-4-5-9-10 (6-8) of the 17-7-16-9 / h4-6, 11 H, 3, 7 H2, h3 1-2
InChIKey:BRILFEZHPXQINW-UHFFFAOYSA-N
SMILES:O1C(C2=CC=C3OCOC3=C2)C1(C)C(OCC)=O
Chemical properties Methyl piperonyl epoxy-propionate is a white solid at room temperature and pressure. By means of the epoxy unit in its structure, the compound can react with a series of nucleophiles to prepare the corresponding methyl piperonyl derivatives. Methyl piperonyl epoxypropionate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical chemical production process. Synthesis In a dry reaction flask, the styrene precursor compound (2mmol) of methyl piperonyl epoxypropionate was dissolved in dichloromethane chemicalbookane (20mL), and the resulting reaction solution was cooled to 0 ° C. M-chloroperoxybenzoic acid (863mg,5mmol) was slowly added to the mixture, and the resulting reaction mixture was stirred at room temperature for 15 hours. After the reaction, the mixture was extracted three times with dichloromethane, all organic layers were combined, then the organic layer was washed with 5%NaHCO3 solution and salt water successively, the organic layer was dried with anhydrous sodium sulfate, and the desiccant was removed by filtration. The filtrate obtained was concentrated under vacuum to obtain the target product molecules.
China
