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ChemicalBook Product Catalog Pitstop 2

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Pitstop 2 NEW

$34.00 1mg

$80.00 5mg

$139.00 10mg

Min. Order
Purity99.54%
Cas No1419320-73-2
Supply Ability10g
Update time2026-02-25

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	Pitstop 2
CAS No	1419320-73-2
EC-No
Min. Order
Purity	99.54%
Supply Ability	10g
Release date	2026/02/25

Product Introduction

Bioactivity

Name	Pitstop 2
Description	Pitstop2 is an amphipathic protein-bound inhibitor of the clathrin terminal domain (IC50=12 μM) with selectivity. Pitstop2 severely interferes with receptor-mediated endocytosis, HIV entry and synaptic vesicle cycling. Pitstop2 has antitumor activity.
In vitro	METHODS: HeLa cells were pre-incubated with Pitstop2 (10-30 µM) for 15 min, followed by incubation with Alexa568-Tf for 15 min, and transferrin (Tf) uptake was detected by live cell microscopy. RESULTS: HeLa cells efficiently internalized Tf into perinuclear circulating endosomes when exposed to Alexa56-Tf. Preincubation of HeLa cells with Pitstop2 resulted in a dose-dependent inhibition of Tf uptake with IC50 values of 12-15 µM, which was very similar to that measured by in vitro blockade of the function of lattice protein TD. [1] METHODS: Asynchronously growing HeLa cells were treated with Pitstop2 (0.001-100 µM) for 6 h and assayed for mitotic index. RESULTS: Acute treatment of HeLa cells with Pitstop2 for 6 h resulted in a significant increase in mitotic index, suggesting that Pitstop2 activates the SAC. The effect of Pitstop2 on mitotic index was concentration-dependent, and significant at concentrations as low as 0.01 µM. [2]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 22 mg/mL (46.48 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.23 mM), Sonication is recommended.
Keywords	Pitstop-2 \| Pitstop2 \| Pitstop 2 \| Inhibitor \| inhibit \| endocytosis \| CME \| clathrin-mediated \| clathrin \| cancer \| Apoptosis
Inhibitors Related	Stavudine \| Aceglutamide \| Tamoxifen \| Urea \| Cysteamine hydrochloride \| Gum arabic \| Sodium 4-phenylbutyrate \| Metronidazole \| Citric Acid Triammonium \| Dimethyl phthalate \| Alginic acid \| Dextran sulfate sodium salt (MW 5000)
Related Compound Libraries	Apoptosis Compound Library \| Bioactive Compound Library \| Inhibitor Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library \| Anti-Cancer Active Compound Library

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