| Name | Pim-1/2 kinase inhibitor 1 |
| Description | Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1]. |
| In vitro | Pim-1/2 kinase inhibitor 1 (compound D14) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM after 48 hours of incubation at varying concentrations [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (212.53 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | Pim2 | Pim-1/2 kinase inhibitor 1 | Pim1 | 2,4Thiazolidinedione, 5pmethoxybenzylidene | 2,4 Thiazolidinedione, 5 p methoxybenzylidene |
| Inhibitors Related | XL413 hydrochloride | HJ-PI01 | SGI-1776 | CK2/ERK8-IN-1 | M-110 | (Z)-SMI-4a | CX-6258 hydrochloride | Pim-1 kinase inhibitor 4 | Pim-1 kinase inhibitor 8 | XL413 xHCl | TP-3654 | K00135 |
| Related Compound Libraries | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Hematonosis Compound Library | JAK-STAT Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Prostate Cancer Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |